834 The roles of plasma versus local pyrophosphate in ectopic calcification disorders
نویسندگان
چکیده
Ectopic calcification is characterized by inappropriate deposition of hydroxyapatite in non-skeletal connective tissues and can cause significant morbidity mortality, particularly when it affects the cardiovascular system. Identification metabolic genetic determinants ectopic could help distinguish individuals at greatest risk developing these pathological calcifications guide development medical interventions. Inorganic pyrophosphate (PPi) has long been recognized as most potent endogenous inhibitor biomineralization. It intensively studied both a marker potential therapeutic for calcification. Decreased extracellular concentrations PPi have proposed to be unifying pathophysiological mechanism disorders calcification, acquired. However, reduced plasma reliable predictor calcification? This presentation evaluates literature favor against role versus tissue PPidysregulation determinant of, biomarker for,
منابع مشابه
Plasma pyrophosphate and vascular calcification in chronic kidney disease.
BACKGROUND Pyrophosphate (PPi) is a potent inhibitor of vascular calcification and may be deficient in renal failure. We sought to determine whether plasma PPi is affected by dialysis or the mode of dialysis and whether it correlates with vascular calcification. METHODS PPi was measured in plasma samples stored from a recent study of vascular calcification in 54 HD patients, 23 peritoneal dia...
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Plasma levels of pyrophosphate, an endogenous inhibitor of vascular calcification, are reduced in end-stage renal disease and correlate inversely with arterial calcification. However, it is not known whether the low plasma levels are directly pathogenic or are merely a marker of reduced tissue levels. This was tested in an animal model in which aortas were transplanted between normal mice and E...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2023
ISSN: ['1523-1747', '0022-202X']
DOI: https://doi.org/10.1016/j.jid.2023.03.844